- #End - A comedy series twisting anime, games, real-life issues, and the haphazard life of college.
- Eagle DNA - Comics by Bob Scott.
- Edible Dirt - Dark, odd humor. Not for everyone. Not for kids. By Matt Rosemier.
- El Goonish Shive - A series about a group of teenagers and the bizarre, often supernatural, situations that they face.
- Elf Life - Daily internet comic strip features myth, slapstick and adventure. By Carson Fire. With background information and archive.
- Elf Only Inn - Cut and paste comic about role playing chatrooms - includes archive of past comics and character profiles.
- Elsie Hooper - Features a black and white serial that appears in the Umass Daily Collegian. Created by Robert D. Krzykowski.
- Emergency Exit - Features a cartoon about crazy roommates, giant hammers, hidden closets of doom, and evil chickens plotting world domination. Includes an archive and a list of characters.
- Empty Trash Talk - A mis-users guide to the language of computerspeak.
- End Times - Following four girls and their dates with destiny.
- Error 804 - Gallery of toons and an about cast and crew. By Chris Hutton.
- Eternal Caffeine Junkie - Funny color strip by Stephanie Burrows.
- Everyday Decay - Webcomic about everyday life in a zombie infested world. By Derrick Ravey.
- Everyday People Cartoons - About women - includes reader kudos and information about the creator. By Cathy Thorne.
- Evil Love Comic - A "bong head" and his beer drinking genius pal, Simon.
- Existence Unknown - Science fiction and adventure webcomic with some humor, created by Martin Borgman.
- Experiments In College Ruled - A webcomic detailing the woes of High School life. Updated Weekly.
- Explosm.net - Home of the "Cyanide and Happiness" strip.
- Extra Life - A cartoon about and for gamers. By Scott Johnson.
- FoundComics.net - Webcomic created by taking a stream of random photos from the internet and adding captions to make them appear to be a complete story.
- The Elf Squad - Comic strip appearing in the occasional school newspaper and weekly community newspaper. By Gary Hoffman.
