- Fair Game - Stephanie Piro's daily comic with a twist!
- Falling Down Productions - Downfall is a comic about a group of displaced Minneapolis city kids attending school in small town. Also features Half Truths.
- Falling Dream - A weekly web comic strip in color, by Greg Tuft. Featuring ad parodies, internet and political humor, and social satire.
- Fan Page of Nurse Frisky - Featuring a frightening, out-of-control nurse.
- Fanboy Almanac - Weekly about the life and times of four average comic book/sci-fi/pop culture fanboys.
- FANS - The story of a few science-fiction fans caught in real science-fiction adventures.
- Farcus - Daily panel comic by David Waislass and Gordon Goulthart. Featuring daily color cartoon (with 2-week archive), postcards, and chats with the creators.
- Fat Jesus - The adventures of a obese defective clone of Jesus.
- Fergo and Enrique - Two animal children learn about life; also, single-panel gag cartoons. By Robert M. Blake.
- Few and Far Between - Regularly-updated comic by Joda Thayer with a cast of child-like characters tangled up in the curtain that divides the mythic from the mundane. Contains calendar to download, character profiles and archive.
- Field of Sheep - Features a collection of sheep cartoons doodles.
- Fishead Tackle - Features daily cartoons, stories, tips and pictures about fishing.
- Fishy Comics - Australian strip by Richard Jones, all about fishing.
- Flail - Comic about the semi-realistic lives of some people - includes past strips.
- Flea Snobbery - Webcomic covering topics including science, technology and religion. By Andrés Diplotti.
- Flem Comics - Appealing to those with no soul left to destroy. By James L. Grant.
- Framed - An ongoing saga about some poor unfortunates who get trapped in a G-Rated comic strip. Includes archived strips.
- Frank, Hank and Charles - The adventures of three sort-of friends. Features an archive, cast and about the comic.
- Frank and Ernest - The official site.
- Frankenstudent - A young Frankenstein comes to America - and enters the third grade. Online comic updated Mon-Thur. Site also contains unrelated single-panel comic updated Fridays.
- Fray, Brian - Portfolio of panels and humorous illustration by the cartoonist.
- Fred and Frank - The crazy cartoon adventures of two soldiers stationed in Germany from 1979 until 1992. Written and illustrated by Charles Kaufman.
- Freddy and Co - A comedic webtoon featuring famous people and talking cats and trees. As styled by a teen.
- From The Desk Of - A cartoon site that sometimes has no actual drawings.
- FS666: the Fatsquad - The official home of the Fatsquad, NH's most controversial comic strip that doesn't care who they make mad.
- Functionbad.com - A comic strip about real life events. Updated regularly. Includes archives and guest art.
- The Family Monster - Features a gallery, the characters, and archives. By Josh Shalek.
- The Fan - Taking place in Iraq and featuring the adventures of two soldiers Dehn and Kensou X, this series offers a way for its creators to keep sane from the middle of a war.
