- Ida Arts - A gallery of cartoons about a misfortunate cat named Cas.
- Idiom Syndrome - A photo-webcomic with random humour for the most part.
- If Life was as Simple as a Webcomic - A gallery of cartoons. By Richard Lewis.
- In Real Life - Following the adventures of Mario, Mega Man, and Link when they are sucked out of the Super NES.
- In the Bleachers - Steve Moore's syndicated humor cartoon about sports.
- In The Puddle - Semi-reality webcomic by Cique Johnson, about bisexual, lesbian and straight young adults in Philadelphia - starring artist and pastafarian Cique, her guy, and pet bat.
- Inepto.com - Lampoons ineptitude at all levels of society, from customer service to CEOs and politicians.
- Inktank.com - Two strips: Angst Technology, about a game development company, and Weak-end Warriors, about paintball.
- Innies and Outties - Funny comic strip about two latchkey kids imagining their way through the enchanted land of suburbia. By Leonard Cachola.
- Intelligent Humor - Offbeat comic, also known as "Big Meaty Chunks", by Chris Williams. Collected by Steven Dengler of Xenon Labs.
- Irregular Webcomic! - Lego and gaming photo comics by David Morgan-Mar.
- Is This Tomorrow? - Features collections, a history, and archives of various strips. Created by Kelly Shane and Woody Compton.
- Isometric - A comic strip drawn entirely with isometric perspective cubes.
- The Imp - A humor strip about hell, by Jose Arroyo and Robin Reed.
- The Infirm - Humor comic about a first-year associate attorney.
- The Invisible Life of Poet - Social commentary through the eyes of a child. By Christopher Wilson.
