- Odd Jobs - David DiAngelo's modern day strip Odd Jobs.
- Off the Mark - Mark Parisi's daily comic panel is on the web with a daily cartoon, archives according to subject, some stuff to buy and syndication information.
- Office Supplies - Humorous strip about everyday items used in the office and their personal take on life. Created by Lola Akinmade.
- Onion Head Monster - Strange comics and animations about this misunderstood monster. By Paul Friedrich.
- Order of the Stick - Fantasy role playing oriented strip - includes cast of characters and some game design articles.
- Orneryboy by Michael Lalonde - A comic strip about the adventures of a really moody boy and his perky girlfriend.
- OsigmaComics - Features webcomic about a school in the UK featuring all the stereotypical characters and situations like world domination.
- Otaku Life - An online comic strip about the secret life of college students and anime freaks. By Jeanette Brown.
- Outta Toon - The official web site of the humor comic strip Outta Toon.
- Over The Edge - Daily Web panel cartoon by Dan Reynolds. With selected past cartoons archived, and originals, cards and t-shirts to buy.
- Overdue Media - Home of "Unshelved". Set in a library by Bill Banes and Gene Ambaum.
- Owlie Comics - An archive featuring the grumpy owl fighting his battles with the universe.
- Ozy and Millie - Two young foxes endure the trials and tribulations of childhood.
- The Ordinary Adventures of Tomas - Photo-comic about Tomas, an invisible friend who doesn't realize he is invisible, and his many ordinary adventures.
